Shin-biology regulated by protein lifetime

Grant-in-Aid for Transformative Research Areas (A) FY2023–FY2027, MEXT Japan

Publicly Offered Research

Publicly Offerred Research of 2024, 25
  • A01
    Elucidation of endogenous defective proteins using newly-developed probes.
    Hiroyuki Kawahara
    School of Science, Tokyo Metropolitan University
  • A01
    Comprehensive identification and lifetime analysis of endoplasmic reticulum-associated degradative substrates in embryogenesis.
    Yukiko Yoshida
    Tokyo Metropolitan Institute of Medical Science
  • A01
    Analysis of nutritional response and adaptation mechanism of cells based on comprehensive measurement of protein half-life
    Kunio Nakatsukasa
    Graduate School of Science, Nagoya City University
  • A01
    Analysis of protein lifetime regulation by TRIM ubiquitin ligases
    Shigetsugu Hatakeyama
    Faculty of Medicine and Graduate School of Medicine, Hokkaido University
  • A02
    Mechanism of lifetime determination of ubiquitinated proteins by selective autophagy
    Hideaki Morishita
    Department of Molecular Cell Biology, Graduate School of Medical Sciences, Kyushu University
  • A02
    Understanding quality control mechanisms of degradation apparatus that determine protein lifetime
    Jun-ichi Sakamaki
    Juntendo University Graduate School of Medicine
  • A02
    Lysosomal Damage Responses Underling Protein Lifetime Regulation
    Akiko Kuma
    Osaka University graduate School of medicine
  • A02
    Analysis of the p97 and its cofactors response to SUMO and branched ubiquitin chains
    Yusuke Sato
    Faculty of Engineering, Tottori University
  • A02
    A New Substrate Recognition Mechanism for Ubiquitination by Hetero-Ubiquitin Ligases
    Kanae Yumimoto
    Department of Chemistry, Faculty of Science, Kyushu University
  • A02
    Molecular mechanisms underlying turnover of lysosomal proteins and their role in aging
    Shuhei Nakamura
    Department of Biochemistry, Nara Medical University
  • A02
    Protein Lifetime Regulation by Linear Poly-ubiquitination
    Daisuke Oikawa
    Department of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University
  • A02
    Regulation of protein lifetime via transient incorporation into p62 droplets
    Hirokazu Arimoto
    Graduate School of Life Sciences, Tohoku University
  • A02
    Analysis of Mechanisms Determining Protein Stability in the Golgi Apparatus
    Shigeomi Shimizu
    Dept. of Pathological Cell Biology, Tokyo Medical and Dental University
  • A02
    Structural Basis for Lifetime Regulation of Mitochondrial Proteins
    Kei Okatsu
    Graduate School of Science, Kyoto University
  • A03
    De-novo protein production technologies for evaluation and regulation of protein lifetime
    Gosuke Hayashi
    Nagoya University Department of Biomolecular Engineering, Graduate School of Engineering
  • A03
    Bump and Hole modification of IAP antagonist-IAP pairs for a novel protein degradation system
    Mikihiko Naito
    Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • A03
    Prediction of protein lifetime with large protein language models
    Toshiyuki Tanaka
    Graduate School of Informatics, Kyoto University