Shin-biology regulated by protein lifetime
Grant-in-Aid for Transformative Research Areas (A) FY2023–FY2027, MEXT Japan
Planned Research
Administrative Group
Shin-biology regulated by protein lifetime
Head Investigator Shigeo Murata
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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A01-1
Protein lifetime dynamics in cell and organ senescence
Shigeo Murata
Graduate School of Pharmaceutical Sciences, The University of Tokyo -
A01-2
Protein Lifespan Dynamics in Neural Stem Cells
Taeko Kobayashi
Graduate School of Biostudies, Kyoto University -
A01-3
Alteration of protein lifetime in vascular stenosis
Daisuke Morito
Showa University School of Medicine
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A02-1
Mechanism of how the proteasome determines protein lifetime
Yasushi Saeki
Division of Protein Metabolism, The Institute of Medical Science, The University of Tokyo -
A02-2
Regulation of the protein lifespan by the ubiquitin code
Fumiaki Ohtake
Hoshi University -
A02-3
Regulation of lifespan of organelle component proteins
Koji Yamano
Medical Research Institute, Tokyo Medical and Dental University
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A03-1
Development of Large-Scale Measurement Methods for Protein Lifetimes and Elucidation of Lifetime Control Principles
Yasushi Ishihama
Graduate School of Pharmaceutical Sciences, Kyoto University -
A03-2
Controlling protein lifespan with the auxin-inducible degron technology
Masato Kanemaki
National Institute of Genetics -
A03-3
Controlling the lifetime of proteins using small-molecule degraders
Yosuke Demizu
Division of Organic Chemistry, National Institute of Health Sciences