タンパク質寿命が制御するシン・バイオロジー

Shin-biology regulated by protein lifetime
文部科学省 科学研究費補助金 学術変革領域研究(A) 令和5年〜9年度

Planned Research

A02
Regulation of protein lifetime via transient incorporation into p62 droplets
Hirokazu Arimoto
Professor, Graduate School of Life Sciences, Tohoku University
https://www.lifesci.tohoku.ac.jp/en/research/fields/laboratory---id-7811.html
researchmap: https://researchmap.jp/read0121317
Abstract

We have been studying targeted protein degraders called autophagy-targeting chimera (AUTACs), in which intracellular phase separation, in particular the p62 body, plays an important role. Here, we investigate cellular proteins that are transiently incorporated into the p62 body under different conditions.

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