タンパク質寿命が制御するシン・バイオロジー

Lysosomes play an essential role in cellular and organismal homeostasis, through their function as degradative organelles and a signaling hub. However, how lysosomal homeostasis is maintained is not well understood. Especially, how the turnover of more than 150 lysosomal membrane proteins and 50 hydrolytic enzymes is regulated remains largely elusive. It has also been reported that lysosomal function declines with age, but the underlying mechanism for this decline and its causal relationship to aging are unclear. In this study, we will clarify the molecular mechanisms of lysosomal protein turnover and its role in aging.

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