タンパク質寿命が制御するシン・バイオロジー

There are several intracellular proteolytic systems, such as the ubiquitin-proteasome system, autophagy and endoplasmic reticulum-associated degradation (ERAD). In addition to these, we have discovered a new proteolytic system, namely Golgi-membrane-associated degradation (GOMED), which regulates the lifespan of various proteins transported via the Golgi to the plasma membrane and extracellular space. GOMED has unique features, such as regulating the lifespan of specific intracellular proteins in response to the extracellular environment, and is an important analytical target for understanding the principles of protein lifespan.
In this study, the following studies will be mainly carried out. (i) comprehensive identification of proteins whose lifetimes are determined by GOMED, (ii) the mechanism by which the lifetimes of these proteins are determined, and (iii) the mechanism by which the lifetimes of proteins in the cell are determined in response to the extracellular environment.

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