タンパク質寿命が制御するシン・バイオロジー

本研究班では、ケミカルノックダウン技術を活用することでタンパク質寿命を人為的に制御できるケミカルバイオロジー研究を遂行する。特に、細胞内タンパク質レベルの時空間制御を可能にできる次世代型PROTACsやMolecular Gluesの開発を目指す。また、セレブロン（CRBN）の元の機能・生理的役割を明らかにし、薬剤結合時における元の機能への影響・干渉を解明するとともに、CRBN以外のE3アダプタータンパク質の機能解析・解明を試みる。さらに、奇形性関連ネオ基質分解を回避するサリドマイド型PROTACやMolecular Glue Degradersの開発を目指す。

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