A02
リソソーム構成タンパク質のターンオーバーを担う分子機構と老化における役割の解明
中村 修平
奈良県立医科大学医学部 教授
https://bioch.naramed-u.ac.jp/index.html
researchmap: https://researchmap.jp/shuhei
奈良県立医科大学医学部 教授
https://bioch.naramed-u.ac.jp/index.html
researchmap: https://researchmap.jp/shuhei
概要
- Cui M., Yamano K., Yamamoto K., Yamamoto-Imoto H., Minami S., Yamamoto T., Matsui S., Kaminishi T., Shima T., Ogura M., Tsuchiya M., Nishino K., Layden B. T., Kato H., Ogawa H., Oki S., Okada Y., Isaka Y., Kosako H., Matsuda N., Yoshimori T., & Nakamura S. (2024) HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence. Proc Natl Acad Sci U S A. 10.1073/pnas.2306454120
- Ogura M., Kaminishi T., Shima T., Torigata M., Bekku N., Tabata K., Minami S., Nishino K., Nezu A., Hamasaki M., Kosako H., Yoshimori T., & Nakamura S. (2023) Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging . EMBO Rep. 10.15252/embr.202357300
- Shioda T., Takahashi I., Ikenaka K., Fujita N., Kanki T., Oka T., Mochizuki H., Antebi A., Yoshimori T., & Nakamura S. (2023) Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity. Proc Natl Acad Sci U S A. 10.1073/pnas.2221553120
- Nakamura S., Shigeyama S., Minami S., Shima T., Akayama S., Matsuda T., Esposito A., Napolitano G., Kuma A., Namba-Hamano T., Nakamura J., Yamamoto K., Sasai M., Tokumura A., Miyamoto M., Oe Y., Fujita T., Terawaki S., Takahashi A., Hamasaki M., Yamamoto M., Okada Y., Komatsu M., Nagai T., Takabatake Y., Xu H., Isaka Y., Ballabio A., & Yoshimori T. (2020) LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury. Nat Cell Biol. 22, 1252–1263
- Nakamura S., Oba M., Suzuki M., Takahashi A., Yamamuro T., Fujiwara M., Ikenaka K., Minami S., Tabata N., Yamamoto K., Kubo S., Tokumura A., Akamatsu K., Miyazaki Y., Kawabata T., Hamasaki M., Fukui K., Sango K., Watanabe Y., Takabatake Y., Kitajima T. S., Okada Y., Mochizuki H., Isaka Y., Antebi A., & Yoshimori T. (2019) Suppression of autophagic activity by Rubicon is a signature of aging. Nat Commun. 10.1038/s41467-019-08729-6